Skip to main content

Advertisement

Log in

Couple Interdependence Impacts Alcohol Use and Adherence to Antiretroviral Therapy in Malawi

  • Original Paper
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

In sub-Saharan Africa, harmful alcohol use among male drinkers is high and has deleterious consequences on adherence to antiretroviral therapy (ART), HIV clinical outcomes, and couple relationship dynamics. We conducted in-depth qualitative interviews with 25 Malawian couples on ART to understand how relationships influence adherence to ART, in which alcohol use emerged as a major theme. Almost half of men (40%) reported current or past alcohol use. Although alcohol use was linked to men’s non-adherence, women buffered this harm by encouraging husbands to reduce alcohol use and by offering adherence support when men were drinking. Men’s drinking interfered with being an effective treatment guardian for wives on ART and also weakened couple support systems needed for adherence. Relationship challenges including food insecurity, intimate partner violence, and extramarital relationships appeared to exacerbate the negative consequences of alcohol use on ART adherence. In this setting, alcohol may be best understood as a couple-level issue. Alcohol interventions for people living with HIV should consider approaches that jointly engage both partners.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Galvan FH, Bing EG, Fleishman JA, et al. The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: results from the HIV Cost and Services Utilization Study. J Stud Alcohol. 2002;63(2):179–86.

    Article  PubMed  Google Scholar 

  2. Hendershot CS, Stoner SA, Pantalone DW, et al. Alcohol use and antiretroviral adherence: review and meta-analysis. J Acquir Immune Defic Syndr. 2009;52(2):180–202.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Giordano TP, Hartman C, Gifford AL, et al. Predictors of retention in HIV care among a national cohort of US veterans. HIV Clin Trials. 2009;10(5):299–305.

    Article  PubMed  Google Scholar 

  4. Chander G, Lau B, Moore RD. Hazardous alcohol use: a risk factor for non-adherence and lack of suppression in HIV infection. J Acquir Immune Defic Syndr. 2006;43(4):411.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Baum MK, Rafie C, Lai S, et al. Alcohol use accelerates HIV disease progression. AIDS Res Hum Retroviruses. 2010;26(5):511–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hahn JA, Samet JH. Alcohol and HIV disease progression: weighing the evidence. Curr HIV/AIDS Rep. 2010;7(4):226–33.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Braithwaite RS, Bryant KJ. Influence of alcohol consumption on adherence to and toxicity of antiretroviral therapy and survival. Alcohol Res Health. 2010;33(3):280.

    PubMed  PubMed Central  Google Scholar 

  8. Kekwaletswe CT, Morojele NK. Alcohol use, antiretroviral therapy adherence, and preferences regarding an alcohol-focused adherence intervention in patients with human immunodeficiency virus. Patient Prefer Adherence. 2014;8:401–13.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Conroy AA, McKenna SA, Leddy A, et al. “If she is drunk, I don’t want her to take it”: partner beliefs and influence on use of alcohol and antiretroviral therapy in South African couples. AIDS Behav. 2017;21(7):1885–91.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Fatch R, Emenyonu NI, Muyindike W, et al. Alcohol interactive toxicity beliefs and ART non-adherence among HIV-infected current drinkers in Mbarara, Uganda. AIDS Behav. 2016;21(7):1812–24.

    Article  Google Scholar 

  11. Kalichman SC, Amaral CM, White D, et al. Prevalence and clinical implications of interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapies among people living with HIV/AIDS. AIDS Patient Care STDS. 2009;23(6):449–54.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kalichman SC, Amaral CM, White D, et al. Alcohol and adherence to antiretroviral medications: interactive toxicity beliefs among people living with HIV. J Assoc Nurses AIDS Care. 2012;23(6):511–20.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Levitt A, Derrick JL, Testa M. Relationship-specific alcohol expectancies and gender moderate the effects of relationship drinking contexts on daily relationship functioning. J Stud Alcohol Drugs. 2014;75(2):269–78.

    PubMed  Google Scholar 

  14. Levitt A, Cooper ML. Daily alcohol use and romantic relationship functioning: evidence of bidirectional, gender-, and context-specific effects. Pers Soc Psychol Bull. 2010;36(12):1706–22.

    Article  PubMed  Google Scholar 

  15. Homish GG, Leonard KE. Marital quality and congruent drinking. J Stud Alcohol. 2005;66(4):488–96.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Rodriguez LM, Neighbors C, Knee CR. Problematic alcohol use and marital distress: an interdependence theory perspective. Addict Res Theory. 2014;22(4):294–312.

    Article  Google Scholar 

  17. Leonard KE, Rothbard JC. Alcohol and the marriage effect. J Stud Alcohol (supplement). 1999;13:139–46.

    Article  CAS  Google Scholar 

  18. Gotlib IH, McCabe SB. Marriage and psychopathology. In: Fincham F, Bradbury T, editors. The psychology of marriage. New York: Guilford; 1990. p. 226–57.

    Google Scholar 

  19. Halford WK, Bouma R, Kelly A, et al. Individual psychopathology and marital distress: analyzing the association and implications for therapy. Behav Modif. 1999;23(2):179–216.

    Article  CAS  PubMed  Google Scholar 

  20. O’Farrell T, Rotunda R. Couples interventions and alcohol abuse. In: Halford W, Markman H, editors. Clinical handbook of marriage and couples interventions. Chichester: Wiley; 1997. p. 555–88.

    Google Scholar 

  21. Homish GG, Leonard KE. The drinking partnership and marital satisfaction: the longitudinal influence of discrepant drinking. J Consult Clin Psychol. 2007;75(1):43.

    Article  PubMed  PubMed Central  Google Scholar 

  22. World Health Organization. Global status report on alcohol and health. Geneva, Switzerland: World Health Organization; 2014.

    Google Scholar 

  23. Morojele NK, Kekwaletswe CT, Nkosi S. Associations between alcohol use, other psychosocial factors, structural factors and antiretroviral therapy (ART) adherence among South African ART recipients. AIDS Behav. 2014;18(3):519–24.

    Article  PubMed  Google Scholar 

  24. Sileo KM, Simbayi LC, Abrams A, et al. The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: event-level findings from a daily diary study. Drug Alcohol Depend. 2016;167:103–11.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Denison JA, Koole O, Tsui S, et al. Incomplete adherence among treatment-experienced adults on antiretroviral therapy in Tanzania, Uganda and Zambia. AIDS (London, England). 2015;29(3):361.

    Article  CAS  Google Scholar 

  26. Ruark A, Kajubi P, Ruteikara S, et al. Couple relationship functioning as a source or mitigator of HIV risk: associations between relationship quality and sexual risk behavior in peri-urban Uganda. AIDS Behav. 2017;22(4):1273–87.

    Article  Google Scholar 

  27. Woolf-King S, Conroy A, Fritz K, et al. Alcohol use and relationship quality among South African couples: implications for couples-based HIV interventions. In: International AIDS conference, 18–22 July 2016, Durban, South Africa; 2016.

  28. Kelley HH, Thibalt JW. Interpersonal relations: a theory of interdependence. New York: Wiley; 1978.

    Google Scholar 

  29. Karney BR, Hops H, Redding CA, et al. A framework for incorporating dyads in models of HIV-prevention. AIDS Behav. 2010;14(2):189–203.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Rusbult C, Arriaga X. Interdependence theory. In: Duck S, editor. Handbook of personal relationships. 2nd ed. London: Wiley; 1997.

    Google Scholar 

  31. Conroy A, Leddy A, Johnson M, et al. ‘I told her this is your life’: relationship dynamics, partner support and adherence to antiretroviral therapy among South African couples. Cult Health Sex. 2017;19(11):1239–53.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Conroy AA, McKenna SA, Comfort ML, et al. Marital infidelity, food insecurity, and couple instability: a web of challenges for dyadic coordination around antiretroviral therapy. Soc Sci Med. 2018;214:110–7.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Singer M. A dose of drugs, a touch of violence, a case of AIDS, part 2: further conceptualizing the SAVA syndemic. Free Inq Creat Sociol. 2006;34(1):39–53.

    Google Scholar 

  34. Singer M. A dose of durgs, a touch of violence, a case of AIDS: conceptualizing the SAVA epidemic. Free Inq Creat Sociol. 1996;24(2):99–110.

    Google Scholar 

  35. Russell BS, Eaton LA, Petersen-Williams P. Intersecting epidemics among pregnant women: alcohol use, interpersonal violence, and HIV infection in South Africa. Curr HIV/AIDS Rep. 2013;10(1):103–10.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Hatcher AM, Colvin CJ, Ndlovud N, et al. Intimate partner violence among rural South African men: alcohol use, sexual decision-making, and partner communication. Cult Health Sex. 2014;16(9):1023–39.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Tsai A, Burns B. Syndemics of psychosocial problems and HIV risk: a systematic review of empirical tests of the disease interaction concept. Soc Sci Med. 2015;139:26–35.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Parsons JT, Grov C, Golub SA. Sexual compulsivity, co-occurring psychosocial health problems, and HIV risk among gay and bisexual men: further evidence of a syndemic. Am J Public Health. 2012;102(1):156–62.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Miller CL, Bangsberg DR, Tuller DM, et al. Food insecurity and sexual risk in an HIV endemic community in Uganda. AIDS Behav. 2011;15:1512–9.

    Article  PubMed  Google Scholar 

  40. Weiser SD, Palar K, Frongillo EA, et al. Longitudinal assessment of associations between food insecurity, antiretroviral adherence and HIV treatment outcomes in rural Uganda. AIDS. 2014;28:115–20.

    Article  CAS  PubMed  Google Scholar 

  41. Weiser SD, Tuller DM, Frongillo EA, et al. Food insecurity as a barrier to sustained antiretroviral therapy adherence in Uganda. PLoS ONE. 2010;5(4):e10340.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Friedman MR, Stall R, Plankey M, et al. Effects of syndemics on HIV viral load and medication adherence in the multicenter AIDS cohort study. AIDS (London, England). 2015;29(9):1087.

    Article  Google Scholar 

  43. Blashill AJ, Bedoya CA, Mayer KH, et al. Psychosocial syndemics are additively associated with worse ART adherence in HIV-infected individuals. AIDS Behav. 2015;19(6):981–6.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Kuhns LM, Hotton AL, Garofalo R, et al. An index of multiple psychosocial, syndemic conditions is associated with antiretroviral medication adherence among HIV-positive youth. AIDS Patient Care STDS. 2016;30(4):185–92.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Starks TJ, Tuck AN, Millar BM, et al. Linking syndemic stress and behavioral indicators of main partner HIV transmission risk in gay male couples. AIDS Behav. 2016;20(2):439–48.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Msyamboza KP, Ngwira B, Dzowela T, et al. The burden of selected chronic non-communicable diseases and their risk factors in Malawi: nationwide STEPS survey. PLoS ONE. 2011;6(5):e20316.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Bush K, Kivlahan D, McDonell M, et al. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Arch Intern Med. 1998;158:1789–95.

    Article  CAS  PubMed  Google Scholar 

  48. National Statistical Office (NSO) [Malawi] and ICF. Malawi Demographic and Health Survey 2015–2016. Zomba: NSO and ICF; 2017.

  49. UNAIDS. UNAIDS Country Report on Malawi. http://www.unaids.org/en/regionscountries/countries/malawi. 2018.

  50. Ministry of Health Malawi. 3rd Edition of the Malawi Guidelines for Clinical Management of HIV in Children and Adults. Malawi: Lilongwe; 2016.

    Google Scholar 

  51. Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–62.

    Article  Google Scholar 

  52. Ritchie J, Lewis J, Nicholls CM, et al. Qualitative research practice: A guide for social science students and researchers. London: Sage; 2013.

    Google Scholar 

  53. Starmann E, Collumbien M, Kyegombe N, et al. Exploring couples’ processes of change in the context of SASA! A violence against women and HIV prevention intervention in Uganda. Prev Sci. 2017;18(2):233–44.

    Article  PubMed  Google Scholar 

  54. Mugweni E, Pearson S, Omar M. Concurrent sexual partnerships among married Zimbabweans—implications for HIV prevention. Int J Women’s Health. 2015;7:819.

    Google Scholar 

  55. Lyimo RA, de Bruin M, van den Boogaard J, et al. Determinants of antiretroviral therapy adherence in northern Tanzania: a comprehensive picture from the patient perspective. BMC Public Health. 2012;12(1):716.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Powers MB, Vedel E, Emmelkamp PM. Behavioral couples therapy (BCT) for alcohol and drug use disorders: a meta-analysis. Clin Psychol Rev. 2008;28(6):952–62.

    Article  PubMed  Google Scholar 

  57. Fals-Stewart W, Clinton-Sherrod M. Treating intimate partner violence among substance-abusing dyads: the effect of couples therapy. Prof Psychol Res Pract. 2009;40(3):257.

    Article  Google Scholar 

  58. Wechsberg WM, Zule WA, El-Bassel N, et al. The male factor: outcomes from a cluster randomized field experiment with a couples-based HIV prevention intervention in a South African township. Drug Alcohol Depend. 2016;161:307–15.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Timko C, Young LB, Moos RH. Al-Anon family groups: origins, conceptual basis, outcomes, and research opportunities. J Groups Addict Recov. 2012;7(2–4):279–96.

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank the tireless efforts of the research staff at Invest in Knowledge in Malawi for data collection.

Funding

This study was funded by the National Institutes of Health under Grants K01MH107331 and T32DA13911.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amy A. Conroy.

Ethics declarations

Conflict of interest

There are no conflicts of interest for any of the study authors.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Conroy, A.A., McKenna, S.A. & Ruark, A. Couple Interdependence Impacts Alcohol Use and Adherence to Antiretroviral Therapy in Malawi. AIDS Behav 23, 201–210 (2019). https://doi.org/10.1007/s10461-018-2275-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-018-2275-2

Keywords

Navigation