The Harrisburg area can expect about 4 to 5 inches of snow Tuesday night through Wednesday.
The National Weather Service in State College expects between four to five inches of snow for the Harrisburg area Wednesday.
But should the storm move further north, the midstate could see up to 8 inches of snow, said meteorologist Tony Mach of the National Weather Service at State College.
The storm likely will drop the most snow south of central Pennsylvania, along the Mason-Dixon Line, however, with Harrisburg sitting on the northern fringe of the weather event, Mach said.
There is a 90 percent chance of snow after midnight Tuesday, with temperatures in the low 30s, he said.
"There's going to be a pretty sharply defined area from where there is snow and heavier snow right now. The best chance for snow is across the southern third of Pennsylvania," Mach said. "It's still a couple days out, and it is subject to change."
Overnight, it will be mostly cloudy with a few snow flurries and temperatures in the low 20s, Mach said.
Monday will be mostly sunny, with a high in the upper 30s.