The purpose of this study was to examine the predictors and consequences associated with Instagram selfie posting. Thus, this study explored whether body image satisfaction predicts Instagram selfie posting and whether Instagram selfie posting is then associated with Instagram-related conflict and negative romantic relationship outcomes. A total of 420 Instagram users aged 18 to 62 years (M = 29.3, SD = 8.12) completed an online survey questionnaire. Analysis of a serial multiple mediator model using bootstrapping methods indicated that body image satisfaction was sequentially associated with increased Instagram selfie posting and Instagram-related conflict, which related to increased negative romantic relationship outcomes. These findings suggest that when Instagram users promote their body image satisfaction in the form of Instagram selfie posts, risk of Instagram-related conflict and negative romantic relationship outcomes might ensue. Findings from the current study provide a baseline understanding to potential and timely trends regarding Instagram selfie posting.