Claire Harrison, MD, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, discusses novel treatment approaches in myeloproliferative neoplasms (MPNs), drawing focus on JAK inhibitors, including ruxolitinib, fedratinib and pacritinib. Prof. Harrison also highlights the MOMENTUM trial (NCT04173494) evaluating the use of momelotinib for the treatment of myelofibrosis. To conclude, Prof. Harrison discusses the importance of using combination therapy for the treatment of myelofibrosis, and the promise that this approach has for the future of MPN treatment. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.