Early biochemical, biophysical, and pharmacological studies led to the conceptualization of receptor activation based on the context of two-state equilibrium ...
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We have derived a two-state acid-base model for cysteine modulation of ligand binding which leads to a description of ligand efficacy. We have shown that pH- ...
Common in these updated two-state model descriptions of GPCR activity is the notion that ligands act by shifting the equilibrium between R and R* and that the ...
... agonist stimulation, it is likely that this free sulfhydryl modulates receptor activation. We have derived a two-state acid-base model for cysteine ...
A. The two-state model of receptor activation vs. multistate models of receptor activation. B. Implications from biophysical studies on receptor ...
Mar 11, 2011 · We have derived a two-state acid-base model for cysteine modulation of ligand binding which leads to a description of ligand efficacy. We have ...
We have derived a two-state acid-base model for cysteine modulation of ligand binding which leads to a description of ligand efficacy. We have shown that pH- ...
Jun 16, 2000 · Activation of G Protein–Coupled Receptors: Beyond Two-State Models and Tertiary Conformational Changes. Annual Review of Pharmacology and ...
Jan 31, 2013 · Simple two-state models, with inactive (R) and active (R*) states in equilibrium, could describe most of their known behaviors. However ...
Dec 4, 2009 · In a two-state forbidden disulfide switch ... Intracellular H2O2 is transiently generated upon activation of receptors ... thiols in molecules with ...
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