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Low-level light therapy improved periocular wrinkles
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Low-level light therapy significantly and safely improved facial skin wrinkles, according to study results published in Dermatologic Surgery.
Researchers in Korea conducted a prospective double-blind study of 52 women aged between 30 and 65 years with more than grade 3 lateral periocular wrinkles.
The patients were randomly divided to receive low-level light therapy using monochromatic 660-nm red light-emitting diodes (LEDs; the red LED group) or polychromatic 411- to 777-nm white LEDS (the white LED group). The entire face was irradiated with 5.17 J from red LEDS or white LEDS for about 10 minutes daily for 12 consecutive weeks. Digital photographs of both lateral periorbital areas in each patient were taken at baseline, 6 weeks and 12 weeks.
There was a significant improvement in wrinkle measurement from skin replica between baseline and week 12 in both cohorts. Although there were no statistical differences between the two treatment groups, the red LED cohort showed slightly better improvement.
No significant differences were observed in both groups during masked assessment by three dermatologists observing digital photographs of both lateral periorbital areas patients were taken at baseline, 6 weeks and 12 weeks.
The red LED group had a mean global improvement score of 1.11 points, which was significantly higher than the white LED group (P = .037).
There were three adverse events reported in the white LED group and nine adverse events reported in the red group, with no statically significant differences. Ocular symptoms, including glare, floaters and blurred vision, were major adverse events, and all adverse events reported were mild with spontaneous recovery.
“This clinical study, which employed both objective and subjective skin analysis techniques, demonstrates the safety and efficacy of 660-nm red EED and 411- to 777-nm white LED home-use devices for the treatment of facial skin wrinkles,” the researchers concluded. “Of the two, the 660-nm red LEDS seemed to be more effective than the 411- to 777-nm white LEDs. Therefore, 660-nm red LED is worth of being considered the first choice for effective, safe and well-tolerated skin rejuvenation using [low-level light therapy].” – by Bruce Thiel
Disclosure: The researchers report no relevant financial disclosures.
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