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Long-term social outcome after pediatric kidney transplantation: a single-center experience

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Abstract

Background

Patient and graft survival rates after pediatric kidney transplantation have improved recently. Therefore, the quality of life or social outcome after kidney transplantation has become important for patients and their families.

Methods

Patients who underwent kidney transplantation at < 18 years old and were observed for > 10 years were included in this study. The median age at first kidney transplantation was 9.2 (interquartile range [IQR] = 5.6–13.0) years; there were 56 males and 50 females. The median age at last follow-up was 29.9 (IQR = 22.2–36.0) years. We evaluated the patients’ renal function, growth, professional status, and marital status at the last follow-up.

Results

The percentage of functioning grafts at the last follow-up was 81.1%; 73 patients (68.9%) had a first graft. The mean estimated GFR was 51.0 ± 20.5 mL/min/1.73 m2. Twenty patients received dialysis for graft failure. The mean final heights of the males and females were 158.1 ± 9.2 cm (− 2.2 standard deviations) and 149.1 ± 6.4 cm (− 1.7 standard deviations), respectively. Excluding 23 students, 63 patients (75.9%) were employed. Office worker was the most common profession. Twelve patients (14.5%) were unemployed. Of patients > 20 years old, 14 (16.7%), three males and 11 females, were married. Five females had one child each.

Conclusions

The graft survival rate was favorable. The final height was short, particularly in male. The rate of employment was relatively high. The rate of marriage and having children were still low. Improving the social outcome is an important problem after pediatric kidney transplantation.

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Acknowledgements

We thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Nephrology, Faculty of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan

    Yuko Hamasaki, Junya Hashimoto, Yujiro Aoki, Mai Kubota, Masaki Muramatsu, Takeshi Kawamura & Ken Sakai

  2. Department of Pediatric Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan

    Seiichiro Shishido

Authors
  1. Yuko Hamasaki
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  2. Junya Hashimoto
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  3. Yujiro Aoki
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  4. Mai Kubota
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  5. Masaki Muramatsu
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  6. Takeshi Kawamura
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  7. Seiichiro Shishido
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  8. Ken Sakai
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Contributions

YH, JH, YA: Participated in research design. YH, JH, MK: Participated in the writing of the paper. YH, JH, YA, MK, MK, MM, SS: Participated in the performance of the research. YH, YA, MM: Participated in data analysis. YH, JH, YA, MK, MM, TK, SS, KS: Drafting the work or revising it critically for important intellectual content. YH, TK, SS, KS: Final approval of the version to be published.

Corresponding author

Correspondence to Yuko Hamasaki.

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Conflict of interest

Yuko Hamasaki belongs to an endowed department sponsored by Asahi Kasei Pharma Corporation, Novartis Pharma K.K., Chugai Pharmaceutical Co., and Astellas Pharma (until 28/Feb/2018). Ken Sakai received annual consultant fees from JMS Co. Ltd. The other authors have no potential conflicts of interest to disclose.

Ethical approval

The study protocol conformed to the Declaration of Helsinki (2008) and was approved by the Toho University Omori Medical Center institutional ethics committees (approval number M 20058).

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Hamasaki, Y., Hashimoto, J., Aoki, Y. et al. Long-term social outcome after pediatric kidney transplantation: a single-center experience. Clin Exp Nephrol 26, 368–375 (2022). https://doi.org/10.1007/s10157-021-02158-w

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  • DOI: https://doi.org/10.1007/s10157-021-02158-w

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