We may find ways to limit or even eradicate certain groups of mosquitoes, and it is wise to evaluate the consequences in advance (Nature 466, 432–434; 2010). We played God with smallpox. Who regrets it?

The idea that mosquitoes preserve nature by keeping humans in check is repugnant and wrong-headed. In the modern era, mortality factors such as malaria do not effectively limit human populations. Reduced fertility is what works. Relieving the burden of malaria will hasten progress to this end.